Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation
المؤلفون المشاركون
Spry, Nigel A.
Taaffe, Dennis R.
Wall, Bradley A.
Galvão, Daniel A.
Fatehee, Naeem
Newton, Robert U.
Joseph, David
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To investigate if androgen deprivation therapy exposure is associated with additional risk factors for cardiovascular disease and metabolic treatment-related toxicities.
Methods.
One hundred and seven men (42–89 years) with prostate cancer undergoing androgen deprivation therapy completed a maximal graded objective exercise test to determine maximal oxygen uptake, assessments for resting metabolic rate, body composition, blood pressure and arterial stiffness, and blood biomarker analysis.
A cross-sectional analysis was undertaken to investigate the potential impact of therapy exposure with participants stratified into two groups according to duration of androgen deprivation therapy (<3 months and ≥3 months).
Results.
Maximal oxygen uptake (26.1 ± 6.0 mL/kg/min versus 23.2 ± 5.8 mL/kg/min, p=0.020) and resting metabolic rate (1795 ± 256 kcal/d versus 1647 ± 236 kcal/d, p=0.005) were significantly higher in those with shorter exposure to androgen deprivation.
There were no differences between groups for peripheral and central blood pressure, arterial stiffness, or metabolic profile.
Conclusion.
Three months or longer exposure to androgen deprivation therapy was associated with reduced cardiorespiratory capacity and resting metabolic rate, but not in a range of blood biomarkers.
These findings suggest that prolonged exposure to androgen deprivation therapy is associated with negative alterations in cardiovascular outcomes.
Trial registry is: ACTRN12609000200280.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wall, Bradley A.& Galvão, Daniel A.& Fatehee, Naeem& Taaffe, Dennis R.& Spry, Nigel A.& Joseph, David…[et al.]. 2015. Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation. Advances in Urology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054008
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wall, Bradley A.…[et al.]. Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation. Advances in Urology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054008
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wall, Bradley A.& Galvão, Daniel A.& Fatehee, Naeem& Taaffe, Dennis R.& Spry, Nigel A.& Joseph, David…[et al.]. Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation. Advances in Urology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054008
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054008
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر