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Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation
Joint Authors
Spry, Nigel A.
Taaffe, Dennis R.
Wall, Bradley A.
Galvão, Daniel A.
Fatehee, Naeem
Newton, Robert U.
Joseph, David
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To investigate if androgen deprivation therapy exposure is associated with additional risk factors for cardiovascular disease and metabolic treatment-related toxicities.
Methods.
One hundred and seven men (42–89 years) with prostate cancer undergoing androgen deprivation therapy completed a maximal graded objective exercise test to determine maximal oxygen uptake, assessments for resting metabolic rate, body composition, blood pressure and arterial stiffness, and blood biomarker analysis.
A cross-sectional analysis was undertaken to investigate the potential impact of therapy exposure with participants stratified into two groups according to duration of androgen deprivation therapy (<3 months and ≥3 months).
Results.
Maximal oxygen uptake (26.1 ± 6.0 mL/kg/min versus 23.2 ± 5.8 mL/kg/min, p=0.020) and resting metabolic rate (1795 ± 256 kcal/d versus 1647 ± 236 kcal/d, p=0.005) were significantly higher in those with shorter exposure to androgen deprivation.
There were no differences between groups for peripheral and central blood pressure, arterial stiffness, or metabolic profile.
Conclusion.
Three months or longer exposure to androgen deprivation therapy was associated with reduced cardiorespiratory capacity and resting metabolic rate, but not in a range of blood biomarkers.
These findings suggest that prolonged exposure to androgen deprivation therapy is associated with negative alterations in cardiovascular outcomes.
Trial registry is: ACTRN12609000200280.
American Psychological Association (APA)
Wall, Bradley A.& Galvão, Daniel A.& Fatehee, Naeem& Taaffe, Dennis R.& Spry, Nigel A.& Joseph, David…[et al.]. 2015. Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation. Advances in Urology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054008
Modern Language Association (MLA)
Wall, Bradley A.…[et al.]. Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation. Advances in Urology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054008
American Medical Association (AMA)
Wall, Bradley A.& Galvão, Daniel A.& Fatehee, Naeem& Taaffe, Dennis R.& Spry, Nigel A.& Joseph, David…[et al.]. Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation. Advances in Urology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054008