Arsenic Primes Human Bone Marrow CD34+ Cells for Erythroid Differentiation
المؤلفون المشاركون
Zhang, Yuanyuan
Wang, Shasha
Chen, Chunyan
Wu, Xiao
Zhang, Qunye
Jiang, Fan
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Arsenic trioxide exhibits therapeutic effects on certain blood malignancies, at least partly by modulating cell differentiation.
Previous in vitro studies in human hematopoietic progenitor cells have suggested that arsenic may inhibit erythroid differentiation.
However, these effects were all observed in the presence of arsenic compounds, while the concomitant cytostatic and cytotoxic actions of arsenic might mask a prodifferentiating activity.
To eliminate the potential impacts of the cytostatic and cytotoxic actions of arsenic, we adopted a novel protocol by pretreating human bone marrow CD34+ cells with a low, noncytotoxic concentration of arsenic trioxide, followed by assaying the colony forming activities in the absence of the arsenic compound.
Bone marrow specimens were obtained from chronic myeloid leukemia patients who achieved complete cytogenetic remission.
CD34+ cells were isolated by magnetic-activated cell sorting.
We discovered that arsenic trioxide enhanced the erythroid colony forming activity, which was accompanied by a decrease in the granulomonocytic differentiation function.
Moreover, in erythroleukemic K562 cells, we showed that arsenic trioxide inhibited erythrocyte maturation, suggesting that arsenic might have biphasic effects on erythropoiesis.
In conclusion, our data provided the first evidence showing that arsenic trioxide could prime human hematopoietic progenitor cells for enhanced erythroid differentiation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yuanyuan& Wang, Shasha& Chen, Chunyan& Wu, Xiao& Zhang, Qunye& Jiang, Fan. 2015. Arsenic Primes Human Bone Marrow CD34+ Cells for Erythroid Differentiation. Bioinorganic Chemistry and Applications،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yuanyuan…[et al.]. Arsenic Primes Human Bone Marrow CD34+ Cells for Erythroid Differentiation. Bioinorganic Chemistry and Applications No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yuanyuan& Wang, Shasha& Chen, Chunyan& Wu, Xiao& Zhang, Qunye& Jiang, Fan. Arsenic Primes Human Bone Marrow CD34+ Cells for Erythroid Differentiation. Bioinorganic Chemistry and Applications. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر