Protecting Intestinal Epithelial Cell Number 6 against Fission Neutron Irradiation through NF-κB Signaling Pathway
المؤلفون المشاركون
Li, Jin-Feng
Chang, Gong-Min
Gao, Ya-Bing
Wang, Shui-Ming
Xu, Xin-Ping
Zhao, Li
Zhang, Jing
Peng, Rui-Yun
Wang, Yunliang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The purpose of this paper is to explore the change of NF-κB signaling pathway in intestinal epithelial cell induced by fission neutron irradiation and the influence of the PI3K/Akt pathway inhibitor LY294002.
Three groups of IEC-6 cell lines were given: control group, neutron irradiation of 4Gy group, and neutron irradiation of 4Gy with LY294002 treatment group.
Except the control group, the other groups were irradiated by neutron of 4Gy.
LY294002 was given before 24 hours of neutron irradiation.
At 6 h and 24 h after neutron irradiation, the morphologic changes, proliferation ability, apoptosis, and necrosis rates of the IEC-6 cell lines were assayed and the changes of NF-κB and PI3K/Akt pathway were detected.
At 6 h and 24 h after neutron irradiation of 4Gy, the proliferation ability of the IEC-6 cells decreased and lots of apoptotic and necrotic cells were found.
The injuries in LY294002 treatment and neutron irradiation group were more serious than those in control and neutron irradiation groups.
The results suggest that IEC-6 cells were obviously damaged and induced serious apoptosis and necrosis by neutron irradiation of 4Gy; the NF-κB signaling pathway in IEC-6 was activated by neutron irradiation which could protect IEC-6 against injury by neutron irradiation; LY294002 could inhibit the activity of IEC-6 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Gong-Min& Gao, Ya-Bing& Wang, Shui-Ming& Xu, Xin-Ping& Zhao, Li& Zhang, Jing…[et al.]. 2015. Protecting Intestinal Epithelial Cell Number 6 against Fission Neutron Irradiation through NF-κB Signaling Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054265
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Gong-Min…[et al.]. Protecting Intestinal Epithelial Cell Number 6 against Fission Neutron Irradiation through NF-κB Signaling Pathway. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054265
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Gong-Min& Gao, Ya-Bing& Wang, Shui-Ming& Xu, Xin-Ping& Zhao, Li& Zhang, Jing…[et al.]. Protecting Intestinal Epithelial Cell Number 6 against Fission Neutron Irradiation through NF-κB Signaling Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054265
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054265
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر