Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study
المؤلفون المشاركون
Ferrari, Cristina
Villano, Carlo
Giacobbi, Beatrice
Coccetti, Daniela
Panichelli, Paola
Niccoli Asabella, Artor
Rubini, Giuseppe
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults with a median survival time less than one year.
To date, there are only a limited number of effective agents available for GBM therapy and this does not seem to add much survival advantage over the conventional approach based on surgery and radiotherapy.
Therefore, the development of novel therapeutic approaches to GBM is essential and those based on radionuclide therapy could be of significant clinical impact.
Experimental evidence has clearly demonstrated that cancer cells have a particularly high fractional content of copper inside the nucleus compared to normal cells.
This behavior can be conveniently exploited both for diagnosis and for delivering therapeutic payloads (theranostic) of the radionuclide copper-64 into the nucleus of cancerous cells by intravenous administration of its simplest chemical form as dichloride salt [64Cu]CuCl2.
To evaluate the potential theranostic role of [64Cu]CuCl2 in GBM, the present work reports results from a preclinical study carried out in a xenografted GBM tumor mouse model.
Biodistribution data of this new agent were collected using a small-animal PET tomograph.
Subsequently, groups of tumor implanted nude mice were treated with [64Cu]CuCl2 to simulate single- and multiple-dose therapy protocols, and results were analyzed to estimate therapeutic efficacy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferrari, Cristina& Niccoli Asabella, Artor& Villano, Carlo& Giacobbi, Beatrice& Coccetti, Daniela& Panichelli, Paola…[et al.]. 2015. Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferrari, Cristina…[et al.]. Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferrari, Cristina& Niccoli Asabella, Artor& Villano, Carlo& Giacobbi, Beatrice& Coccetti, Daniela& Panichelli, Paola…[et al.]. Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر