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Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study
Joint Authors
Ferrari, Cristina
Villano, Carlo
Giacobbi, Beatrice
Coccetti, Daniela
Panichelli, Paola
Niccoli Asabella, Artor
Rubini, Giuseppe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults with a median survival time less than one year.
To date, there are only a limited number of effective agents available for GBM therapy and this does not seem to add much survival advantage over the conventional approach based on surgery and radiotherapy.
Therefore, the development of novel therapeutic approaches to GBM is essential and those based on radionuclide therapy could be of significant clinical impact.
Experimental evidence has clearly demonstrated that cancer cells have a particularly high fractional content of copper inside the nucleus compared to normal cells.
This behavior can be conveniently exploited both for diagnosis and for delivering therapeutic payloads (theranostic) of the radionuclide copper-64 into the nucleus of cancerous cells by intravenous administration of its simplest chemical form as dichloride salt [64Cu]CuCl2.
To evaluate the potential theranostic role of [64Cu]CuCl2 in GBM, the present work reports results from a preclinical study carried out in a xenografted GBM tumor mouse model.
Biodistribution data of this new agent were collected using a small-animal PET tomograph.
Subsequently, groups of tumor implanted nude mice were treated with [64Cu]CuCl2 to simulate single- and multiple-dose therapy protocols, and results were analyzed to estimate therapeutic efficacy.
American Psychological Association (APA)
Ferrari, Cristina& Niccoli Asabella, Artor& Villano, Carlo& Giacobbi, Beatrice& Coccetti, Daniela& Panichelli, Paola…[et al.]. 2015. Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054289
Modern Language Association (MLA)
Ferrari, Cristina…[et al.]. Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054289
American Medical Association (AMA)
Ferrari, Cristina& Niccoli Asabella, Artor& Villano, Carlo& Giacobbi, Beatrice& Coccetti, Daniela& Panichelli, Paola…[et al.]. Copper-64 Dichloride as Theranostic Agent for Glioblastoma Multiforme: A Preclinical Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054289