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Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets
المؤلفون المشاركون
Miyoshi, Anderson
Silva, Artur
Ali, Amjad
Naz, Anam
Soares, Siomar C
Bakhtiar, Marriam
Tiwari, Sandeep
Hassan, Syed S
Hanan, Fazal
Ramos, Rommel
Pereira, Ulisses
Barh, Debmalya
Figueiredo, Henrique César Pereira
Ussery, David W.
Azevedo, Vasco
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-29
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Helicobacter pylori is a human gastric pathogen implicated as the major cause of peptic ulcer and second leading cause of gastric cancer (~70%) around the world.
Conversely, an increased resistance to antibiotics and hindrances in the development of vaccines against H.
pylori are observed.
Pan-genome analyses of the global representative H.
pylori isolates consisting of 39 complete genomes are presented in this paper.
Phylogenetic analyses have revealed close relationships among geographically diverse strains of H.
pylori.
The conservation among these genomes was further analyzed by pan-genome approach; the predicted conserved gene families (1,193) constitute ~77% of the average H.
pylori genome and 45% of the global gene repertoire of the species.
Reverse vaccinology strategies have been adopted to identify and narrow down the potential core-immunogenic candidates.
Total of 28 nonhost homolog proteins were characterized as universal therapeutic targets against H.
pylori based on their functional annotation and protein-protein interaction.
Finally, pathogenomics and genome plasticity analysis revealed 3 highly conserved and 2 highly variable putative pathogenicity islands in all of the H.
pylori genomes been analyzed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Amjad& Naz, Anam& Soares, Siomar C& Bakhtiar, Marriam& Tiwari, Sandeep& Hassan, Syed S…[et al.]. 2015. Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1054339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Amjad…[et al.]. Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1054339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Amjad& Naz, Anam& Soares, Siomar C& Bakhtiar, Marriam& Tiwari, Sandeep& Hassan, Syed S…[et al.]. Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1054339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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