Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets
Joint Authors
Miyoshi, Anderson
Silva, Artur
Ali, Amjad
Naz, Anam
Soares, Siomar C
Bakhtiar, Marriam
Tiwari, Sandeep
Hassan, Syed S
Hanan, Fazal
Ramos, Rommel
Pereira, Ulisses
Barh, Debmalya
Figueiredo, Henrique César Pereira
Ussery, David W.
Azevedo, Vasco
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Helicobacter pylori is a human gastric pathogen implicated as the major cause of peptic ulcer and second leading cause of gastric cancer (~70%) around the world.
Conversely, an increased resistance to antibiotics and hindrances in the development of vaccines against H.
pylori are observed.
Pan-genome analyses of the global representative H.
pylori isolates consisting of 39 complete genomes are presented in this paper.
Phylogenetic analyses have revealed close relationships among geographically diverse strains of H.
pylori.
The conservation among these genomes was further analyzed by pan-genome approach; the predicted conserved gene families (1,193) constitute ~77% of the average H.
pylori genome and 45% of the global gene repertoire of the species.
Reverse vaccinology strategies have been adopted to identify and narrow down the potential core-immunogenic candidates.
Total of 28 nonhost homolog proteins were characterized as universal therapeutic targets against H.
pylori based on their functional annotation and protein-protein interaction.
Finally, pathogenomics and genome plasticity analysis revealed 3 highly conserved and 2 highly variable putative pathogenicity islands in all of the H.
pylori genomes been analyzed.
American Psychological Association (APA)
Ali, Amjad& Naz, Anam& Soares, Siomar C& Bakhtiar, Marriam& Tiwari, Sandeep& Hassan, Syed S…[et al.]. 2015. Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1054339
Modern Language Association (MLA)
Ali, Amjad…[et al.]. Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1054339
American Medical Association (AMA)
Ali, Amjad& Naz, Anam& Soares, Siomar C& Bakhtiar, Marriam& Tiwari, Sandeep& Hassan, Syed S…[et al.]. Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1054339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054339