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Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth
المؤلفون المشاركون
Prat, Annik
Declercq, Jeroen
Brouwers, Bas
Pruniau, Vincent P. E. G.
Stijnen, Pieter
Tuand, Krizia
Meulemans, Sandra
Seidah, Nabil G.
Khatib, Abdel-Majid
Creemers, John W. M.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Proprotein convertases are subtilisin-like serine endoproteases that cleave and hence activate a variety of proproteins, including growth factors, receptors, metalloproteases, and extracellular matrix proteins.
Therefore, it has been suggested that inhibition of the ubiquitously expressed proprotein convertase FURIN might be a good therapeutic strategy for several tumor types.
Whether this is also the case for hepatocellular carcinoma (HCC) is currently not clear.
In a mouse model for HCC expression of Furin was not altered in the tumors, while those of PC7, PC5/6, and PACE4 significantly decreased, at least at some time points.
To investigate the impact of Furin inhibition on the development and progression of HCC in this model, Furin was genetically ablated in the liver.
Furin inactivation resulted in an increased tumor mass after 5 weeks.
This was not caused by decreased apoptosis, since no differences in the apoptosis index could be observed.
However, it could at least partially be explained by increased hepatocyte proliferation at 5 weeks.
The tumors of the Furin knockout mice were histologically similar to those in wild type mice.
In conclusion, liver-specific Furin inhibition in HCC enhances the tumor formation and will not be a good therapeutic strategy for this tumor type.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Declercq, Jeroen& Brouwers, Bas& Pruniau, Vincent P. E. G.& Stijnen, Pieter& Tuand, Krizia& Meulemans, Sandra…[et al.]. 2015. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Declercq, Jeroen…[et al.]. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Declercq, Jeroen& Brouwers, Bas& Pruniau, Vincent P. E. G.& Stijnen, Pieter& Tuand, Krizia& Meulemans, Sandra…[et al.]. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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