An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety
المؤلفون المشاركون
Sa-ngasoongsong, Paphon
Chanplakorn, Pongsthorn
Wongsak, Siwadol
Uthadorn, Krisorn
Panpikoon, Tanapong
Jittorntam, Paisan
Aryurachai, Katcharin
Angchaisukisiri, Pantap
Kawinwonggowit, Viroj
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Recently, combined intra-articular tranexamic acid (IA-TXA) injection with clamping drain method showed efficacy for blood loss and transfusion reduction in total knee replacement (TKR).
However, until now, none of previous studies revealed the effect of this technique on pharmacokinetics, coagulation, and fibrinolysis.
Materials and Methods.
An experimental study was conducted, during 2011-2012, in 30 patients undergoing unilateral TKR.
Patients received IA-TXA application and then were allocated into six groups regarding clamping drain duration (2-, 4-, 6-, 8-, 10-, and 12-hours).
Blood and drainage fluid were collected to measure tranexamic acid (TXA) level and related coagulation and fibrinolytic markers.
Postoperative complication was followed for one year.
Results.
There was no significant difference of serum TXA level at 2 hour and 24 hour among groups ( p < 0.05 ) .
Serum TXA level at time of clamp release was significantly different among groups with the highest level at 2 hour ( p < 0.0001 ) .
There was no significant difference of TXA level in drainage fluid, postoperative blood loss, blood transfusion, and postoperative complications ( p < 0.05 ) .
Conclusions.
Low-dose IA-TXA application in TKR with prolonged clamping drain method is a safe and effective blood conservative technique with only minimal systemic absorption and without significant increase in systemic absorption over time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sa-ngasoongsong, Paphon& Chanplakorn, Pongsthorn& Wongsak, Siwadol& Uthadorn, Krisorn& Panpikoon, Tanapong& Jittorntam, Paisan…[et al.]. 2015. An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054431
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sa-ngasoongsong, Paphon…[et al.]. An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054431
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sa-ngasoongsong, Paphon& Chanplakorn, Pongsthorn& Wongsak, Siwadol& Uthadorn, Krisorn& Panpikoon, Tanapong& Jittorntam, Paisan…[et al.]. An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054431
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054431
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر