An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety
Joint Authors
Sa-ngasoongsong, Paphon
Chanplakorn, Pongsthorn
Wongsak, Siwadol
Uthadorn, Krisorn
Panpikoon, Tanapong
Jittorntam, Paisan
Aryurachai, Katcharin
Angchaisukisiri, Pantap
Kawinwonggowit, Viroj
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recently, combined intra-articular tranexamic acid (IA-TXA) injection with clamping drain method showed efficacy for blood loss and transfusion reduction in total knee replacement (TKR).
However, until now, none of previous studies revealed the effect of this technique on pharmacokinetics, coagulation, and fibrinolysis.
Materials and Methods.
An experimental study was conducted, during 2011-2012, in 30 patients undergoing unilateral TKR.
Patients received IA-TXA application and then were allocated into six groups regarding clamping drain duration (2-, 4-, 6-, 8-, 10-, and 12-hours).
Blood and drainage fluid were collected to measure tranexamic acid (TXA) level and related coagulation and fibrinolytic markers.
Postoperative complication was followed for one year.
Results.
There was no significant difference of serum TXA level at 2 hour and 24 hour among groups ( p < 0.05 ) .
Serum TXA level at time of clamp release was significantly different among groups with the highest level at 2 hour ( p < 0.0001 ) .
There was no significant difference of TXA level in drainage fluid, postoperative blood loss, blood transfusion, and postoperative complications ( p < 0.05 ) .
Conclusions.
Low-dose IA-TXA application in TKR with prolonged clamping drain method is a safe and effective blood conservative technique with only minimal systemic absorption and without significant increase in systemic absorption over time.
American Psychological Association (APA)
Sa-ngasoongsong, Paphon& Chanplakorn, Pongsthorn& Wongsak, Siwadol& Uthadorn, Krisorn& Panpikoon, Tanapong& Jittorntam, Paisan…[et al.]. 2015. An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054431
Modern Language Association (MLA)
Sa-ngasoongsong, Paphon…[et al.]. An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054431
American Medical Association (AMA)
Sa-ngasoongsong, Paphon& Chanplakorn, Pongsthorn& Wongsak, Siwadol& Uthadorn, Krisorn& Panpikoon, Tanapong& Jittorntam, Paisan…[et al.]. An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054431