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Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells
المؤلفون المشاركون
Balestrieri, Emanuela
Pica, Francesca
Matteucci, Claudia
Zenobi, Rossella
Sorrentino, Roberta
Argaw-Denboba, Ayele
Cipriani, Chiara
Bucci, Ilaria
Sinibaldi-Vallebona, Paola
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Human endogenous retroviruses (HERVs) have been implicated in human physiology and in human pathology.
A better knowledge of the retroviral transcriptional activity in the general population and during the life span would greatly help the debate on its pathologic potential.
The transcriptional activity of four HERV families (H, K, W, and E) was assessed, by qualitative and quantitative PCR, in PBMCs from 261 individuals aged from 1 to 80 years.
Our results show that HERV-H, HERV-K, and HERV-W, but not HERV-E, are transcriptionally active in the test population already in the early childhood.
In addition, the transcriptional levels of HERV-H, HERV-K, and HERV-W change significantly during the life span, albeit with distinct patterns.
Our results, reinforce the hypothesis of a physiological correlation between HERVs activity and the different stages of life in humans.
Studies aiming at identifying the factors, which are responsible for these changes during the individual’s life, are still needed.
Although the observed phenomena are presumably subjected to great variability, the basal transcriptional activity of each individual, also depending on the different ages of life, must be carefully considered in all the studies involving HERVs as causative agents of disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balestrieri, Emanuela& Pica, Francesca& Matteucci, Claudia& Zenobi, Rossella& Sorrentino, Roberta& Argaw-Denboba, Ayele…[et al.]. 2015. Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054432
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balestrieri, Emanuela…[et al.]. Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054432
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balestrieri, Emanuela& Pica, Francesca& Matteucci, Claudia& Zenobi, Rossella& Sorrentino, Roberta& Argaw-Denboba, Ayele…[et al.]. Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054432
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054432
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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