Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells
Joint Authors
Balestrieri, Emanuela
Pica, Francesca
Matteucci, Claudia
Zenobi, Rossella
Sorrentino, Roberta
Argaw-Denboba, Ayele
Cipriani, Chiara
Bucci, Ilaria
Sinibaldi-Vallebona, Paola
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Human endogenous retroviruses (HERVs) have been implicated in human physiology and in human pathology.
A better knowledge of the retroviral transcriptional activity in the general population and during the life span would greatly help the debate on its pathologic potential.
The transcriptional activity of four HERV families (H, K, W, and E) was assessed, by qualitative and quantitative PCR, in PBMCs from 261 individuals aged from 1 to 80 years.
Our results show that HERV-H, HERV-K, and HERV-W, but not HERV-E, are transcriptionally active in the test population already in the early childhood.
In addition, the transcriptional levels of HERV-H, HERV-K, and HERV-W change significantly during the life span, albeit with distinct patterns.
Our results, reinforce the hypothesis of a physiological correlation between HERVs activity and the different stages of life in humans.
Studies aiming at identifying the factors, which are responsible for these changes during the individual’s life, are still needed.
Although the observed phenomena are presumably subjected to great variability, the basal transcriptional activity of each individual, also depending on the different ages of life, must be carefully considered in all the studies involving HERVs as causative agents of disease.
American Psychological Association (APA)
Balestrieri, Emanuela& Pica, Francesca& Matteucci, Claudia& Zenobi, Rossella& Sorrentino, Roberta& Argaw-Denboba, Ayele…[et al.]. 2015. Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054432
Modern Language Association (MLA)
Balestrieri, Emanuela…[et al.]. Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054432
American Medical Association (AMA)
Balestrieri, Emanuela& Pica, Francesca& Matteucci, Claudia& Zenobi, Rossella& Sorrentino, Roberta& Argaw-Denboba, Ayele…[et al.]. Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054432