Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus
المؤلفون المشاركون
Cabezas-Opazo, Fabián A.
Ezquer, Fernando
Giraud-Billoud, Maximiliano
Carpio, Daniel
Conget, Paulette
Ezquer, Marcelo E.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-08
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
The aim of our work was to evaluate, in an animal model of severe diabetes mellitus, the effect of mesenchymal stem cells (MSCs) administration on diabetic nephropathy (DN) progression.
After diabetes induction, one group of mice received the vehicle (DM) and other group received a single dose of MSCs (DM + MSCs).
DM + MSCs mice showed a significant improvement in functional parameters of the kidney compared with untreated mice.
While DM mice presented marked histopathological changes characteristics of advanced stages of DN (fibrosis, glomerulosclerosis, glomerular basement membrane thickening, capillary occlusion, decreased podocyte density, and effacement of foot processes), DM + MSCs mice showed only slight tubular dilatation.
The renoprotection was not associated with an improvement in diabetic condition and very low number of donor cells was found in the kidney of DM + MSCs mice, suggesting that renoprotection could be mediated by paracrine effects.
Indeed, DM + MSC mice presented increased renal proliferation index, decreased renal apoptotic index and the restoration of proregenerative factors, and anti-inflammatory cytokines levels.
Moreover, macrophage infiltration and oxidative stress damage were also reduced in DM + MSCs mice.
Our data demonstrate that MSC administration triggers a proregenerative microenvironment in DN kidney, which allows the preservation of the renal function even if diabetes was uncorrected.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ezquer, Fernando& Giraud-Billoud, Maximiliano& Carpio, Daniel& Cabezas-Opazo, Fabián A.& Conget, Paulette& Ezquer, Marcelo E.. 2015. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. BioMed Research International،Vol. 2015, no. 2015, pp.1-23.
https://search.emarefa.net/detail/BIM-1054435
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ezquer, Fernando…[et al.]. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. BioMed Research International No. 2015 (2015), pp.1-23.
https://search.emarefa.net/detail/BIM-1054435
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ezquer, Fernando& Giraud-Billoud, Maximiliano& Carpio, Daniel& Cabezas-Opazo, Fabián A.& Conget, Paulette& Ezquer, Marcelo E.. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-23.
https://search.emarefa.net/detail/BIM-1054435
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054435
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر