Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus
Joint Authors
Cabezas-Opazo, Fabián A.
Ezquer, Fernando
Giraud-Billoud, Maximiliano
Carpio, Daniel
Conget, Paulette
Ezquer, Marcelo E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-08
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The aim of our work was to evaluate, in an animal model of severe diabetes mellitus, the effect of mesenchymal stem cells (MSCs) administration on diabetic nephropathy (DN) progression.
After diabetes induction, one group of mice received the vehicle (DM) and other group received a single dose of MSCs (DM + MSCs).
DM + MSCs mice showed a significant improvement in functional parameters of the kidney compared with untreated mice.
While DM mice presented marked histopathological changes characteristics of advanced stages of DN (fibrosis, glomerulosclerosis, glomerular basement membrane thickening, capillary occlusion, decreased podocyte density, and effacement of foot processes), DM + MSCs mice showed only slight tubular dilatation.
The renoprotection was not associated with an improvement in diabetic condition and very low number of donor cells was found in the kidney of DM + MSCs mice, suggesting that renoprotection could be mediated by paracrine effects.
Indeed, DM + MSC mice presented increased renal proliferation index, decreased renal apoptotic index and the restoration of proregenerative factors, and anti-inflammatory cytokines levels.
Moreover, macrophage infiltration and oxidative stress damage were also reduced in DM + MSCs mice.
Our data demonstrate that MSC administration triggers a proregenerative microenvironment in DN kidney, which allows the preservation of the renal function even if diabetes was uncorrected.
American Psychological Association (APA)
Ezquer, Fernando& Giraud-Billoud, Maximiliano& Carpio, Daniel& Cabezas-Opazo, Fabián A.& Conget, Paulette& Ezquer, Marcelo E.. 2015. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. BioMed Research International،Vol. 2015, no. 2015, pp.1-23.
https://search.emarefa.net/detail/BIM-1054435
Modern Language Association (MLA)
Ezquer, Fernando…[et al.]. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. BioMed Research International No. 2015 (2015), pp.1-23.
https://search.emarefa.net/detail/BIM-1054435
American Medical Association (AMA)
Ezquer, Fernando& Giraud-Billoud, Maximiliano& Carpio, Daniel& Cabezas-Opazo, Fabián A.& Conget, Paulette& Ezquer, Marcelo E.. Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-23.
https://search.emarefa.net/detail/BIM-1054435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054435