Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis
المؤلفون المشاركون
de Castro, Leandro Nunes
Redondo-Gonzalez, Enrique
Moreno-Sierra, Jesús
Maestro de las Casas, María Luisa
Vera-Gonzalez, Vicente
Ferrari, Daniel Gomes
Corchado Rodriguez, Juan Manuel
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Bladder cancer occurs in the epithelial lining of the urinary bladder and is amongst the most common types of cancer in humans, killing thousands of people a year.
This paper is based on the hypothesis that the use of clinical and histopathological data together with information about the concentration of various molecular markers in patients is useful for the prediction of outcomes and the design of treatments of nonmuscle invasive bladder carcinoma (NMIBC).
A population of 45 patients with a new diagnosis of NMIBC was selected.
Patients with benign prostatic hyperplasia (BPH), muscle invasive bladder carcinoma (MIBC), carcinoma in situ (CIS), and NMIBC recurrent tumors were not included due to their different clinical behavior.
Clinical history was obtained by means of anamnesis and physical examination, and preoperative imaging and urine cytology were carried out for all patients.
Then, patients underwent conventional transurethral resection (TURBT) and some proteomic analyses quantified the biomarkers (p53, neu, and EGFR).
A postoperative follow-up was performed to detect relapse and progression.
Clusterings were performed to find groups with clinical, molecular markers, histopathological prognostic factors, and statistics about recurrence, progression, and overall survival of patients with NMIBC.
Four groups were found according to tumor sizes, risk of relapse or progression, and biological behavior.
Outlier patients were also detected and categorized according to their clinical characters and biological behavior.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Redondo-Gonzalez, Enrique& de Castro, Leandro Nunes& Moreno-Sierra, Jesús& Maestro de las Casas, María Luisa& Vera-Gonzalez, Vicente& Ferrari, Daniel Gomes…[et al.]. 2015. Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054464
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Redondo-Gonzalez, Enrique…[et al.]. Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054464
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Redondo-Gonzalez, Enrique& de Castro, Leandro Nunes& Moreno-Sierra, Jesús& Maestro de las Casas, María Luisa& Vera-Gonzalez, Vicente& Ferrari, Daniel Gomes…[et al.]. Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054464
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054464
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر