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Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis
Joint Authors
de Castro, Leandro Nunes
Redondo-Gonzalez, Enrique
Moreno-Sierra, Jesús
Maestro de las Casas, María Luisa
Vera-Gonzalez, Vicente
Ferrari, Daniel Gomes
Corchado Rodriguez, Juan Manuel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Bladder cancer occurs in the epithelial lining of the urinary bladder and is amongst the most common types of cancer in humans, killing thousands of people a year.
This paper is based on the hypothesis that the use of clinical and histopathological data together with information about the concentration of various molecular markers in patients is useful for the prediction of outcomes and the design of treatments of nonmuscle invasive bladder carcinoma (NMIBC).
A population of 45 patients with a new diagnosis of NMIBC was selected.
Patients with benign prostatic hyperplasia (BPH), muscle invasive bladder carcinoma (MIBC), carcinoma in situ (CIS), and NMIBC recurrent tumors were not included due to their different clinical behavior.
Clinical history was obtained by means of anamnesis and physical examination, and preoperative imaging and urine cytology were carried out for all patients.
Then, patients underwent conventional transurethral resection (TURBT) and some proteomic analyses quantified the biomarkers (p53, neu, and EGFR).
A postoperative follow-up was performed to detect relapse and progression.
Clusterings were performed to find groups with clinical, molecular markers, histopathological prognostic factors, and statistics about recurrence, progression, and overall survival of patients with NMIBC.
Four groups were found according to tumor sizes, risk of relapse or progression, and biological behavior.
Outlier patients were also detected and categorized according to their clinical characters and biological behavior.
American Psychological Association (APA)
Redondo-Gonzalez, Enrique& de Castro, Leandro Nunes& Moreno-Sierra, Jesús& Maestro de las Casas, María Luisa& Vera-Gonzalez, Vicente& Ferrari, Daniel Gomes…[et al.]. 2015. Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054464
Modern Language Association (MLA)
Redondo-Gonzalez, Enrique…[et al.]. Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054464
American Medical Association (AMA)
Redondo-Gonzalez, Enrique& de Castro, Leandro Nunes& Moreno-Sierra, Jesús& Maestro de las Casas, María Luisa& Vera-Gonzalez, Vicente& Ferrari, Daniel Gomes…[et al.]. Bladder Carcinoma Data with Clinical Risk Factors and Molecular Markers: A Cluster Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054464