Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium
المؤلفون المشاركون
Mohamed, Muhamad Idham
Abdul Razak, Khairunisak
Abdul Razak, Hairil Rashmizal
Md Saad, Wan Mazlina
Mohammad, Mohd Khairul Amran
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Emerging syntheses and findings of new metallic nanoparticles (MNPs) have become an important aspect in various fields including diagnostic imaging.
To date, iodine has been utilized as a radiographic contrast medium.
However, the raise concern of iodine threats on iodine-intolerance patient has led to search of new contrast media with lower toxic level.
In this animal modeling study, 14 nm iron oxide nanoparticles (IONPs) with silane-polyethylene glycol (SiPEG) and perchloric acid have been assessed for toxicity level as compared to conventional iodine.
The nanotoxicity of IONPs was evaluated in liver biochemistry, reactive oxygen species production (ROS), lipid peroxidation mechanism, and ultrastructural evaluation using transmission electron microscope (TEM).
The hematological analysis and liver function test (LFT) revealed that most of the liver enzymes were significantly higher in iodine-administered group as compared to those in normal and IONPs groups P < 0.05 .
ROS production assay and lipid peroxidation indicator, malondialdehyde (MDA), also showed significant reductions in comparison with iodine group P < 0.05 .
TEM evaluation yielded the aberration of nucleus structure of iodine-administered group as compared to those in control and IONPs groups.
This study has demonstrated the less toxic properties of IONPs and it may postulate that IONPs are safe to be applied as radiographic contrast medium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamed, Muhamad Idham& Mohammad, Mohd Khairul Amran& Abdul Razak, Hairil Rashmizal& Abdul Razak, Khairunisak& Md Saad, Wan Mazlina. 2015. Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054531
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamed, Muhamad Idham…[et al.]. Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054531
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamed, Muhamad Idham& Mohammad, Mohd Khairul Amran& Abdul Razak, Hairil Rashmizal& Abdul Razak, Khairunisak& Md Saad, Wan Mazlina. Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054531
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054531
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر