![](/images/graphics-bg.png)
Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium
Joint Authors
Mohamed, Muhamad Idham
Abdul Razak, Khairunisak
Abdul Razak, Hairil Rashmizal
Md Saad, Wan Mazlina
Mohammad, Mohd Khairul Amran
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Emerging syntheses and findings of new metallic nanoparticles (MNPs) have become an important aspect in various fields including diagnostic imaging.
To date, iodine has been utilized as a radiographic contrast medium.
However, the raise concern of iodine threats on iodine-intolerance patient has led to search of new contrast media with lower toxic level.
In this animal modeling study, 14 nm iron oxide nanoparticles (IONPs) with silane-polyethylene glycol (SiPEG) and perchloric acid have been assessed for toxicity level as compared to conventional iodine.
The nanotoxicity of IONPs was evaluated in liver biochemistry, reactive oxygen species production (ROS), lipid peroxidation mechanism, and ultrastructural evaluation using transmission electron microscope (TEM).
The hematological analysis and liver function test (LFT) revealed that most of the liver enzymes were significantly higher in iodine-administered group as compared to those in normal and IONPs groups P < 0.05 .
ROS production assay and lipid peroxidation indicator, malondialdehyde (MDA), also showed significant reductions in comparison with iodine group P < 0.05 .
TEM evaluation yielded the aberration of nucleus structure of iodine-administered group as compared to those in control and IONPs groups.
This study has demonstrated the less toxic properties of IONPs and it may postulate that IONPs are safe to be applied as radiographic contrast medium.
American Psychological Association (APA)
Mohamed, Muhamad Idham& Mohammad, Mohd Khairul Amran& Abdul Razak, Hairil Rashmizal& Abdul Razak, Khairunisak& Md Saad, Wan Mazlina. 2015. Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054531
Modern Language Association (MLA)
Mohamed, Muhamad Idham…[et al.]. Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054531
American Medical Association (AMA)
Mohamed, Muhamad Idham& Mohammad, Mohd Khairul Amran& Abdul Razak, Hairil Rashmizal& Abdul Razak, Khairunisak& Md Saad, Wan Mazlina. Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054531