MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance
المؤلفون المشاركون
Yan, Zi-Xun
Zheng, Zhong
Xue, Wen
Zhao, Ming-Zhe
Fei, Xiao-Chun
Wu, Li-Li
Huang, Li-Min
Leboeuf, Christophe
Wang, Li
Zhao, Wei-Li
Janin, Anne
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRs) play an important role in tumorogenesis and chemoresistance in lymphoid malignancies.
Comparing with reactive hyperplasia, miR181a was overexpressed in 130 patients with T-cell leukemia/lymphoma, including acute T-cell lymphoblastic leukemia ( n = 32 ), T-cell lymphoblastic lymphoma ( n = 16 ), peripheral T-cell lymphoma, not otherwise specified ( n = 45 ), anaplastic large cell lymphoma ( n = 15 ), and angioimmunoblastic T-cell lymphoma ( n = 22 ).
Irrespective to histological subtypes, miR181a overexpression was associated with increased AKT phosphorylation.
In vitro, ectopic expression of miR181a in HEK-293T cells significantly enhanced cell proliferation, activated AKT, and conferred cell resistance to doxorubicin.
Meanwhile, miR181a expression was upregulated in Jurkat cells, along with AKT activation, during exposure to chemotherapeutic agents regularly applied to T-cell leukemia/lymphoma treatment, such as doxorubicin, cyclophosphamide, cytarabine, and cisplatin.
Isogenic doxorubicin-resistant Jurkat and H9 cells were subsequently developed, which also presented with miR181a overexpression and cross-resistance to cyclophosphamide and cisplatin.
Meanwhile, specific inhibition of miR181a enhanced Jurkat and H9 cell sensitivity to chemotherapeutic agents, further indicating that miR181a was involved in acquired chemoresistance.
Collectively, miR181a functioned as a biomarker of T-cell leukemia/lymphoma through modulation of AKT pathway.
Related to tumor cell chemoresistance, miR181a could be a potential therapeutic target in treating T-cell malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Zi-Xun& Zheng, Zhong& Xue, Wen& Zhao, Ming-Zhe& Fei, Xiao-Chun& Wu, Li-Li…[et al.]. 2015. MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054596
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Zi-Xun…[et al.]. MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054596
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Zi-Xun& Zheng, Zhong& Xue, Wen& Zhao, Ming-Zhe& Fei, Xiao-Chun& Wu, Li-Li…[et al.]. MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054596
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054596
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر