MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance
Joint Authors
Yan, Zi-Xun
Zheng, Zhong
Xue, Wen
Zhao, Ming-Zhe
Fei, Xiao-Chun
Wu, Li-Li
Huang, Li-Min
Leboeuf, Christophe
Wang, Li
Zhao, Wei-Li
Janin, Anne
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
MicroRNAs (miRs) play an important role in tumorogenesis and chemoresistance in lymphoid malignancies.
Comparing with reactive hyperplasia, miR181a was overexpressed in 130 patients with T-cell leukemia/lymphoma, including acute T-cell lymphoblastic leukemia ( n = 32 ), T-cell lymphoblastic lymphoma ( n = 16 ), peripheral T-cell lymphoma, not otherwise specified ( n = 45 ), anaplastic large cell lymphoma ( n = 15 ), and angioimmunoblastic T-cell lymphoma ( n = 22 ).
Irrespective to histological subtypes, miR181a overexpression was associated with increased AKT phosphorylation.
In vitro, ectopic expression of miR181a in HEK-293T cells significantly enhanced cell proliferation, activated AKT, and conferred cell resistance to doxorubicin.
Meanwhile, miR181a expression was upregulated in Jurkat cells, along with AKT activation, during exposure to chemotherapeutic agents regularly applied to T-cell leukemia/lymphoma treatment, such as doxorubicin, cyclophosphamide, cytarabine, and cisplatin.
Isogenic doxorubicin-resistant Jurkat and H9 cells were subsequently developed, which also presented with miR181a overexpression and cross-resistance to cyclophosphamide and cisplatin.
Meanwhile, specific inhibition of miR181a enhanced Jurkat and H9 cell sensitivity to chemotherapeutic agents, further indicating that miR181a was involved in acquired chemoresistance.
Collectively, miR181a functioned as a biomarker of T-cell leukemia/lymphoma through modulation of AKT pathway.
Related to tumor cell chemoresistance, miR181a could be a potential therapeutic target in treating T-cell malignancies.
American Psychological Association (APA)
Yan, Zi-Xun& Zheng, Zhong& Xue, Wen& Zhao, Ming-Zhe& Fei, Xiao-Chun& Wu, Li-Li…[et al.]. 2015. MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054596
Modern Language Association (MLA)
Yan, Zi-Xun…[et al.]. MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054596
American Medical Association (AMA)
Yan, Zi-Xun& Zheng, Zhong& Xue, Wen& Zhao, Ming-Zhe& Fei, Xiao-Chun& Wu, Li-Li…[et al.]. MicroRNA181a Is Overexpressed in T-Cell LeukemiaLymphoma and Related to Chemoresistance. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054596