Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma
المؤلفون المشاركون
Miracco, Clelia
Toscano, Marzia
Palumbo, Silvia
Pastina, Pierpaolo
Battaglia, Giuseppe
Nardone, Valerio
Butorano, Marie Aimée Gloria Munezero
Masucci, Armando
Cerase, Alfonso
Pirtoli, Luigi
Belmonte, Giuseppe
Tini, Paolo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Dysregulated EGFR in glioblastoma may inactivate the key autophagy protein Beclin1.
Each of high EGFR and low Beclin1 protein expression, independently, has been associated with tumor progression and poor prognosis.
High (H) compared to low (L) expression of EGFR and Beclin1 is here correlated with main clinical data in 117 patients after chemo- and radiotherapy.
H-EGFR correlated with low Karnofsky performance and worse neurological performance status, higher incidence of synchronous multifocality, poor radiological evidence of response, shorter progression disease-free (PDFS), and overall survival (OS).
H-Beclin1 cases showed better Karnofsky performance status, higher incidence of objective response, longer PDFS, and OS.
A mutual strengthening effect emerges in correlative power of stratified L-EGFR and H-Beclin1 expression with incidence of radiological response after treatment, unifocal disease, and better prognosis, thus identifying an even longer OS group (30 months median OS compared to 18 months in L-EGFR, 15 months in H-Beclin1, and 11 months in all GBs) ( P = 0.0001 ).
Combined L-EGFR + H-Beclin1 expression may represent a biomarker in identifying relatively favorable clinical presentations and prognosis, thus envisaging possible EGFR/Beclin1-targeted therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tini, Paolo& Belmonte, Giuseppe& Toscano, Marzia& Miracco, Clelia& Palumbo, Silvia& Pastina, Pierpaolo…[et al.]. 2015. Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tini, Paolo…[et al.]. Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1054636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tini, Paolo& Belmonte, Giuseppe& Toscano, Marzia& Miracco, Clelia& Palumbo, Silvia& Pastina, Pierpaolo…[et al.]. Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر