Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma
Joint Authors
Miracco, Clelia
Toscano, Marzia
Palumbo, Silvia
Pastina, Pierpaolo
Battaglia, Giuseppe
Nardone, Valerio
Butorano, Marie Aimée Gloria Munezero
Masucci, Armando
Cerase, Alfonso
Pirtoli, Luigi
Belmonte, Giuseppe
Tini, Paolo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dysregulated EGFR in glioblastoma may inactivate the key autophagy protein Beclin1.
Each of high EGFR and low Beclin1 protein expression, independently, has been associated with tumor progression and poor prognosis.
High (H) compared to low (L) expression of EGFR and Beclin1 is here correlated with main clinical data in 117 patients after chemo- and radiotherapy.
H-EGFR correlated with low Karnofsky performance and worse neurological performance status, higher incidence of synchronous multifocality, poor radiological evidence of response, shorter progression disease-free (PDFS), and overall survival (OS).
H-Beclin1 cases showed better Karnofsky performance status, higher incidence of objective response, longer PDFS, and OS.
A mutual strengthening effect emerges in correlative power of stratified L-EGFR and H-Beclin1 expression with incidence of radiological response after treatment, unifocal disease, and better prognosis, thus identifying an even longer OS group (30 months median OS compared to 18 months in L-EGFR, 15 months in H-Beclin1, and 11 months in all GBs) ( P = 0.0001 ).
Combined L-EGFR + H-Beclin1 expression may represent a biomarker in identifying relatively favorable clinical presentations and prognosis, thus envisaging possible EGFR/Beclin1-targeted therapies.
American Psychological Association (APA)
Tini, Paolo& Belmonte, Giuseppe& Toscano, Marzia& Miracco, Clelia& Palumbo, Silvia& Pastina, Pierpaolo…[et al.]. 2015. Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054636
Modern Language Association (MLA)
Tini, Paolo…[et al.]. Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1054636
American Medical Association (AMA)
Tini, Paolo& Belmonte, Giuseppe& Toscano, Marzia& Miracco, Clelia& Palumbo, Silvia& Pastina, Pierpaolo…[et al.]. Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054636