Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet
المؤلفون المشاركون
Xu, Hua
Hu, Meng-bo
Bai, Pei-de
Zhu, Wen-hui
Liu, Sheng-hua
Hou, Jun-yao
Xiong, Zu-quan
Ding, Qiang
Jiang, Hao-wen
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
We aimed to examine whether proinflammatory cytokines participated in prostate cancer (PCa) development and progression promoted by high-fat diet (HFD).
Methods.
TRAMP (transgenic adenocarcinoma mouse prostate) mice were randomly divided into two groups: normal diet group and HFD group.
Mortality rate and tumor formation rate were examined.
TRAMP mice were sacrificed and sampled on the 20th, 24th, and 28th week, respectively.
Levels of proinflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, were tested by FlowCytomix.
Prostate tissue of TRAMP mice was used for histology study.
Results.
A total of 13 deaths of TRAMP mice were observed, among which 3 (8.33%) were from the normal diet group and 10 (27.78%) from the HFD group.
The mortality rate of TRAMP mice from HFD group was significantly higher than that of normal diet group (P=0.032).
Tumor formation rate at 20th week of age of HFD group was significantly higher than that of normal diet group (P=0.045).
Proinflammatory cytokines levels, including IL-1α, IL-1β, IL-6, and TNF-α, were significantly higher in HFD TRAMP mice.
Conclusions.
HFD could promote TRAMP mouse PCa development and progression with elevated proinflammatory cytokines levels.
Proinflammatory cytokines could contribute to PCa development and progression promoted by HFD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Hua& Hu, Meng-bo& Bai, Pei-de& Zhu, Wen-hui& Liu, Sheng-hua& Hou, Jun-yao…[et al.]. 2015. Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054753
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Hua…[et al.]. Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054753
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Hua& Hu, Meng-bo& Bai, Pei-de& Zhu, Wen-hui& Liu, Sheng-hua& Hou, Jun-yao…[et al.]. Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054753
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054753
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر