Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet
Joint Authors
Xu, Hua
Hu, Meng-bo
Bai, Pei-de
Zhu, Wen-hui
Liu, Sheng-hua
Hou, Jun-yao
Xiong, Zu-quan
Ding, Qiang
Jiang, Hao-wen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
We aimed to examine whether proinflammatory cytokines participated in prostate cancer (PCa) development and progression promoted by high-fat diet (HFD).
Methods.
TRAMP (transgenic adenocarcinoma mouse prostate) mice were randomly divided into two groups: normal diet group and HFD group.
Mortality rate and tumor formation rate were examined.
TRAMP mice were sacrificed and sampled on the 20th, 24th, and 28th week, respectively.
Levels of proinflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, were tested by FlowCytomix.
Prostate tissue of TRAMP mice was used for histology study.
Results.
A total of 13 deaths of TRAMP mice were observed, among which 3 (8.33%) were from the normal diet group and 10 (27.78%) from the HFD group.
The mortality rate of TRAMP mice from HFD group was significantly higher than that of normal diet group (P=0.032).
Tumor formation rate at 20th week of age of HFD group was significantly higher than that of normal diet group (P=0.045).
Proinflammatory cytokines levels, including IL-1α, IL-1β, IL-6, and TNF-α, were significantly higher in HFD TRAMP mice.
Conclusions.
HFD could promote TRAMP mouse PCa development and progression with elevated proinflammatory cytokines levels.
Proinflammatory cytokines could contribute to PCa development and progression promoted by HFD.
American Psychological Association (APA)
Xu, Hua& Hu, Meng-bo& Bai, Pei-de& Zhu, Wen-hui& Liu, Sheng-hua& Hou, Jun-yao…[et al.]. 2015. Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054753
Modern Language Association (MLA)
Xu, Hua…[et al.]. Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054753
American Medical Association (AMA)
Xu, Hua& Hu, Meng-bo& Bai, Pei-de& Zhu, Wen-hui& Liu, Sheng-hua& Hou, Jun-yao…[et al.]. Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054753