Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks
المؤلفون المشاركون
Yang, Lei
Tang, Xianglong
Liu, Peng
Shi, Daming
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A method for predicting protein-protein interactions based on detected protein complexes is proposed to repair deficient interactions derived from high-throughput biological experiments.
Protein complexes are pruned and decomposed into small parts based on the adaptive k-cores method to predict protein-protein interactions associated with the complexes.
The proposed method is adaptive to protein complexes with different structure, number, and size of nodes in a protein-protein interaction network.
Based on different complex sets detected by various algorithms, we can obtain different prediction sets of protein-protein interactions.
The reliability of the predicted interaction sets is proved by using estimations with statistical tests and direct confirmation of the biological data.
In comparison with the approaches which predict the interactions based on the cliques, the overlap of the predictions is small.
Similarly, the overlaps among the predicted sets of interactions derived from various complex sets are also small.
Thus, every predicted set of interactions may complement and improve the quality of the original network data.
Meanwhile, the predictions from the proposed method replenish protein-protein interactions associated with protein complexes using only the network topology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Peng& Yang, Lei& Shi, Daming& Tang, Xianglong. 2015. Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Peng…[et al.]. Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Peng& Yang, Lei& Shi, Daming& Tang, Xianglong. Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر