Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks
Joint Authors
Yang, Lei
Tang, Xianglong
Liu, Peng
Shi, Daming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A method for predicting protein-protein interactions based on detected protein complexes is proposed to repair deficient interactions derived from high-throughput biological experiments.
Protein complexes are pruned and decomposed into small parts based on the adaptive k-cores method to predict protein-protein interactions associated with the complexes.
The proposed method is adaptive to protein complexes with different structure, number, and size of nodes in a protein-protein interaction network.
Based on different complex sets detected by various algorithms, we can obtain different prediction sets of protein-protein interactions.
The reliability of the predicted interaction sets is proved by using estimations with statistical tests and direct confirmation of the biological data.
In comparison with the approaches which predict the interactions based on the cliques, the overlap of the predictions is small.
Similarly, the overlaps among the predicted sets of interactions derived from various complex sets are also small.
Thus, every predicted set of interactions may complement and improve the quality of the original network data.
Meanwhile, the predictions from the proposed method replenish protein-protein interactions associated with protein complexes using only the network topology.
American Psychological Association (APA)
Liu, Peng& Yang, Lei& Shi, Daming& Tang, Xianglong. 2015. Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054788
Modern Language Association (MLA)
Liu, Peng…[et al.]. Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054788
American Medical Association (AMA)
Liu, Peng& Yang, Lei& Shi, Daming& Tang, Xianglong. Prediction of Protein-Protein Interactions Related to Protein Complexes Based on Protein Interaction Networks. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054788