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Cultivated Oral Mucosa Epithelium in Ocular Surface Reconstruction in Aniridia Patients
المؤلفون المشاركون
Wylęgała, Edward
Dobrowolski, Dariusz
Aragona, Pasquale
Puzzolo, Domenico
Micali, Antonio
Orzechowska-Wylegala, Boguslawa
Wowra, Bogumil
Wroblewska-Czajka, Ewa
Grolik, Maria
Szczubialka, Krzysztof
Nowakowska, Maria
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Efficacy of cultivated oral mucosa epithelial transplantation (COMET) procedure in corneal epithelium restoration of aniridia patients.
Methods.
Study subjects were aniridia patients (13 patients; 17 eyes) with irregular, vascular conjunctival pannus involving visual axis who underwent autologous transplantation of cultivated epithelium.
For the procedure oral mucosa epithelial cells were obtained from buccal mucosa with further enzymatic treatment.
Suspension of single cells was seeded on previously prepared denuded amniotic membrane.
Cultures were carried on culture dishes inserts in the presence of the inactivated with Mitomycin C monolayer of 3T3 fibroblasts.
Cultures were carried for seven days.
Stratified oral mucosa epithelium with its amniotic membrane carrier was transplanted on the surgically denuded corneal surface of aniridia patients with total or subtotal limbal stem cell deficiency.
Outcome Measures.
Corneal surface, epithelial regularity, and visual acuity improvement were evaluated.
Results.
At the end of the observation period, 76.4% of the eyes had regular transparent epithelium and 23.5% had developed epithelial defects or central corneal haze; in 88.2% of cases visual acuity had increased.
VA range was from HM 0.05 before the surgery to HM up to 0.1 after surgery.
Conclusion.
Application of cultivated oral mucosa epithelium restores regular epithelium on the corneal surface with moderate improvement in quality of vision.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dobrowolski, Dariusz& Orzechowska-Wylegala, Boguslawa& Wowra, Bogumil& Wroblewska-Czajka, Ewa& Grolik, Maria& Szczubialka, Krzysztof…[et al.]. 2015. Cultivated Oral Mucosa Epithelium in Ocular Surface Reconstruction in Aniridia Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054867
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dobrowolski, Dariusz…[et al.]. Cultivated Oral Mucosa Epithelium in Ocular Surface Reconstruction in Aniridia Patients. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054867
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dobrowolski, Dariusz& Orzechowska-Wylegala, Boguslawa& Wowra, Bogumil& Wroblewska-Czajka, Ewa& Grolik, Maria& Szczubialka, Krzysztof…[et al.]. Cultivated Oral Mucosa Epithelium in Ocular Surface Reconstruction in Aniridia Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054867
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054867
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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