Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus
المؤلفون المشاركون
Jeong, Seung-Il
Kim, Su Young
Kim, Ju
Jahng, Kwang Yeop
Yu, Kang-Yeol
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The antimicrobial killing activity toward methicillin-resistant Staphylococcus aureus (MRSA) has been a serious emerging global issue.
In a continuing search for compounds with antibacterial activity against several microorganisms including S.
aureus and MRSA, an n-hexane extract of Magnolia officinalis was found to contain magnolol.
This compound exhibited potent activity against S.
aureus, standard methicillin-susceptible S.
aureus (MSSA), and MRSA as well as clinical MRSA isolates.
When combined with oxacillin, the antibacterial activities of magnolol and honokiol against the MRSA strain were increased compared to single treatment without antibiotics at 10 µg/mL and 25 µg/mL, respectively.
These activities of magnolol and honokiol were dose dependent.
Also, magnolol showed synergistic effects with oxacillin against 13 clinical isolates of MRSA.
It was determined that magnolol and honokiol had a synergistic effect with oxacillin against MRSA strain.
Furthermore, the magnolol inhibited the expression of the resistant genes, mecA, mecI, femA, and femB, in mRNA.
We concluded that the antibacterial activity of magnolol against MRSA strain is more related to the mecI’s pathway and components of the cell wall than mecR1.
Therefore, the results obtained in this study suggest that the combination of magnolol and antibiotics could lead to the development of new combination antibiotics against MRSA infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Su Young& Kim, Ju& Jeong, Seung-Il& Jahng, Kwang Yeop& Yu, Kang-Yeol. 2015. Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054879
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Su Young…[et al.]. Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054879
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Su Young& Kim, Ju& Jeong, Seung-Il& Jahng, Kwang Yeop& Yu, Kang-Yeol. Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054879
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054879
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر