Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus
Joint Authors
Jeong, Seung-Il
Kim, Su Young
Kim, Ju
Jahng, Kwang Yeop
Yu, Kang-Yeol
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The antimicrobial killing activity toward methicillin-resistant Staphylococcus aureus (MRSA) has been a serious emerging global issue.
In a continuing search for compounds with antibacterial activity against several microorganisms including S.
aureus and MRSA, an n-hexane extract of Magnolia officinalis was found to contain magnolol.
This compound exhibited potent activity against S.
aureus, standard methicillin-susceptible S.
aureus (MSSA), and MRSA as well as clinical MRSA isolates.
When combined with oxacillin, the antibacterial activities of magnolol and honokiol against the MRSA strain were increased compared to single treatment without antibiotics at 10 µg/mL and 25 µg/mL, respectively.
These activities of magnolol and honokiol were dose dependent.
Also, magnolol showed synergistic effects with oxacillin against 13 clinical isolates of MRSA.
It was determined that magnolol and honokiol had a synergistic effect with oxacillin against MRSA strain.
Furthermore, the magnolol inhibited the expression of the resistant genes, mecA, mecI, femA, and femB, in mRNA.
We concluded that the antibacterial activity of magnolol against MRSA strain is more related to the mecI’s pathway and components of the cell wall than mecR1.
Therefore, the results obtained in this study suggest that the combination of magnolol and antibiotics could lead to the development of new combination antibiotics against MRSA infection.
American Psychological Association (APA)
Kim, Su Young& Kim, Ju& Jeong, Seung-Il& Jahng, Kwang Yeop& Yu, Kang-Yeol. 2015. Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054879
Modern Language Association (MLA)
Kim, Su Young…[et al.]. Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054879
American Medical Association (AMA)
Kim, Su Young& Kim, Ju& Jeong, Seung-Il& Jahng, Kwang Yeop& Yu, Kang-Yeol. Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054879