Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model

المؤلفون المشاركون

Hirahara, Ichiro
Kusano, Eiji
Imai, Toshimi
Morishita, Yoshiyuki
Muto, Shigeaki
Sato, Hideki
Onishi, Akira
Nagata, Daisuke

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-05-03

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Peritoneal dialysis (PD) is a common treatment for patients with reduced or absent renal function.

Long-term PD leads to peritoneal injury with structural changes and functional decline.

At worst, peritoneal injury leads to encapsulating peritoneal sclerosis (EPS), which is a serious complication of PD.

In order to carry out PD safely, it is important to define the mechanism of progression of peritoneal injury and EPS.

We prepared rat models of peritoneal injury by intraperitoneal administration of glucose degradation products, such as methylglyoxal (MGO) or formaldehyde (FA), chlorhexidine gluconate (CG), and talc.

In rats treated with MGO, peritoneal fibrous thickening with the appearance of basophilic spindle cells with podoplanin, cytokeratin, and α-smooth muscle actin at the surface of the peritoneum was observed.

These cells may have been derived from mesothelial cells by epithelial-to-mesenchymal transition.

In FA- or CG-treated rats, the peritoneum was thickened, and mesothelial cells were absent at the surface of the peritoneum.

The CG- or MGO-treated rats presented with a so-called abdominal cocoon.

In the talc-treated rats, extensive peritoneal adhesion and peritoneal thickening were observed.

MGO-induced peritoneal injury model may reflect human histopathology and be suitable to analyze the mechanism of progression of peritoneal injury and EPS.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hirahara, Ichiro& Sato, Hideki& Imai, Toshimi& Onishi, Akira& Morishita, Yoshiyuki& Muto, Shigeaki…[et al.]. 2015. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054906

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hirahara, Ichiro…[et al.]. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054906

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hirahara, Ichiro& Sato, Hideki& Imai, Toshimi& Onishi, Akira& Morishita, Yoshiyuki& Muto, Shigeaki…[et al.]. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054906

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1054906