Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model
المؤلفون المشاركون
Hirahara, Ichiro
Kusano, Eiji
Imai, Toshimi
Morishita, Yoshiyuki
Muto, Shigeaki
Sato, Hideki
Onishi, Akira
Nagata, Daisuke
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Peritoneal dialysis (PD) is a common treatment for patients with reduced or absent renal function.
Long-term PD leads to peritoneal injury with structural changes and functional decline.
At worst, peritoneal injury leads to encapsulating peritoneal sclerosis (EPS), which is a serious complication of PD.
In order to carry out PD safely, it is important to define the mechanism of progression of peritoneal injury and EPS.
We prepared rat models of peritoneal injury by intraperitoneal administration of glucose degradation products, such as methylglyoxal (MGO) or formaldehyde (FA), chlorhexidine gluconate (CG), and talc.
In rats treated with MGO, peritoneal fibrous thickening with the appearance of basophilic spindle cells with podoplanin, cytokeratin, and α-smooth muscle actin at the surface of the peritoneum was observed.
These cells may have been derived from mesothelial cells by epithelial-to-mesenchymal transition.
In FA- or CG-treated rats, the peritoneum was thickened, and mesothelial cells were absent at the surface of the peritoneum.
The CG- or MGO-treated rats presented with a so-called abdominal cocoon.
In the talc-treated rats, extensive peritoneal adhesion and peritoneal thickening were observed.
MGO-induced peritoneal injury model may reflect human histopathology and be suitable to analyze the mechanism of progression of peritoneal injury and EPS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hirahara, Ichiro& Sato, Hideki& Imai, Toshimi& Onishi, Akira& Morishita, Yoshiyuki& Muto, Shigeaki…[et al.]. 2015. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hirahara, Ichiro…[et al.]. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hirahara, Ichiro& Sato, Hideki& Imai, Toshimi& Onishi, Akira& Morishita, Yoshiyuki& Muto, Shigeaki…[et al.]. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر