![](/images/graphics-bg.png)
Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice
المؤلفون المشاركون
Wang, Zhigang
Luo, Guanghua
Feng, Yuehua
Zheng, Lu
Liu, Hongyao
Liang, Yun
Liu, Zhonghua
Shao, Peng
Berggren-Söderlund, Maria
Zhang, Xiaoying
Xu, Ning
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Spleen T-lymphocytes, especially CD4+ T-cells, have been demonstrated to be involved in broad immunomodulation and host-defense activity in vivo.
Apolipoprotein M gene (apoM) may have an important role in the regulation of immunoprocess and inflammation, which could be hypothesized to the apoM containing sphingosine-1-phosphate (S1P).
In the present study we demonstrate that the splenic CD4+ T-lymphocytes were obviously decreased in the apoM gene deficient (apoM−/−) mice compared to the wild type (apoM+/+).
Moreover, these mice were treated with lipopolysaccharide (LPS) and it was found that even more pronounced decreasing CD4+ T-lymphocytes occurred in the spleen compared to the apoM+/+ mice.
The similar phenomena were found in the ratio of CD4+/CD8+ T-lymphocytes.
After administration of LPS, the hepatic mRNA levels of tumor necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1) were markedly increased; however, there were no statistical differences observed between apoM+/+ mice and apoM−/− mice.
The present study demonstrated that apoM might facilitate the maintenance of CD4+ T-lymphocytes or could modify the T-lymphocytes subgroups in murine spleen, which may further explore the importance of apoM in the regulation of the host immunomodulation, although the detailed mechanism needs continuing investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhigang& Luo, Guanghua& Feng, Yuehua& Zheng, Lu& Liu, Hongyao& Liang, Yun…[et al.]. 2015. Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhigang…[et al.]. Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhigang& Luo, Guanghua& Feng, Yuehua& Zheng, Lu& Liu, Hongyao& Liang, Yun…[et al.]. Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)