Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice
Joint Authors
Wang, Zhigang
Luo, Guanghua
Feng, Yuehua
Zheng, Lu
Liu, Hongyao
Liang, Yun
Liu, Zhonghua
Shao, Peng
Berggren-Söderlund, Maria
Zhang, Xiaoying
Xu, Ning
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Spleen T-lymphocytes, especially CD4+ T-cells, have been demonstrated to be involved in broad immunomodulation and host-defense activity in vivo.
Apolipoprotein M gene (apoM) may have an important role in the regulation of immunoprocess and inflammation, which could be hypothesized to the apoM containing sphingosine-1-phosphate (S1P).
In the present study we demonstrate that the splenic CD4+ T-lymphocytes were obviously decreased in the apoM gene deficient (apoM−/−) mice compared to the wild type (apoM+/+).
Moreover, these mice were treated with lipopolysaccharide (LPS) and it was found that even more pronounced decreasing CD4+ T-lymphocytes occurred in the spleen compared to the apoM+/+ mice.
The similar phenomena were found in the ratio of CD4+/CD8+ T-lymphocytes.
After administration of LPS, the hepatic mRNA levels of tumor necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1) were markedly increased; however, there were no statistical differences observed between apoM+/+ mice and apoM−/− mice.
The present study demonstrated that apoM might facilitate the maintenance of CD4+ T-lymphocytes or could modify the T-lymphocytes subgroups in murine spleen, which may further explore the importance of apoM in the regulation of the host immunomodulation, although the detailed mechanism needs continuing investigation.
American Psychological Association (APA)
Wang, Zhigang& Luo, Guanghua& Feng, Yuehua& Zheng, Lu& Liu, Hongyao& Liang, Yun…[et al.]. 2015. Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054934
Modern Language Association (MLA)
Wang, Zhigang…[et al.]. Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054934
American Medical Association (AMA)
Wang, Zhigang& Luo, Guanghua& Feng, Yuehua& Zheng, Lu& Liu, Hongyao& Liang, Yun…[et al.]. Decreased Splenic CD4 + T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054934