Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes
المؤلفون المشاركون
Requena, Jose M.
Montalvo-Álvarez, Ana M.
Fraga, Jorge
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-18
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Molecular chaperones are key components in the maintenance of cellular homeostasis and survival, not only during stress but also under optimal growth conditions.
Folding of nascent polypeptides is supported by molecular chaperones, which avoid the formation of aggregates by preventing nonspecific interactions and aid, when necessary, the translocation of proteins to their correct intracellular localization.
Furthermore, when proteins are damaged, molecular chaperones may also facilitate their refolding or, in the case of irreparable proteins, their removal by the protein degradation machinery of the cell.
During their digenetic lifestyle, Leishmania parasites encounter and adapt to harsh environmental conditions, such as nutrient deficiency, hypoxia, oxidative stress, changing pH, and shifts in temperature; all these factors are potential triggers of cellular stress.
We summarize here our current knowledge on the main types of molecular chaperones in Leishmania and their functions.
Among them, heat shock proteins play important roles in adaptation and survival of this parasite against temperature changes associated with its passage from the poikilothermic insect vector to the warm-blooded vertebrate host.
The study of structural features and the function of chaperones in Leishmania biology is providing opportunities (and challenges) for drug discovery and improving of current treatments against leishmaniasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Requena, Jose M.& Montalvo-Álvarez, Ana M.& Fraga, Jorge. 2015. Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. BioMed Research International،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1054959
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Requena, Jose M.…[et al.]. Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. BioMed Research International No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1054959
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Requena, Jose M.& Montalvo-Álvarez, Ana M.& Fraga, Jorge. Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1054959
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054959
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر