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Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes
Joint Authors
Requena, Jose M.
Montalvo-Álvarez, Ana M.
Fraga, Jorge
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-18
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Molecular chaperones are key components in the maintenance of cellular homeostasis and survival, not only during stress but also under optimal growth conditions.
Folding of nascent polypeptides is supported by molecular chaperones, which avoid the formation of aggregates by preventing nonspecific interactions and aid, when necessary, the translocation of proteins to their correct intracellular localization.
Furthermore, when proteins are damaged, molecular chaperones may also facilitate their refolding or, in the case of irreparable proteins, their removal by the protein degradation machinery of the cell.
During their digenetic lifestyle, Leishmania parasites encounter and adapt to harsh environmental conditions, such as nutrient deficiency, hypoxia, oxidative stress, changing pH, and shifts in temperature; all these factors are potential triggers of cellular stress.
We summarize here our current knowledge on the main types of molecular chaperones in Leishmania and their functions.
Among them, heat shock proteins play important roles in adaptation and survival of this parasite against temperature changes associated with its passage from the poikilothermic insect vector to the warm-blooded vertebrate host.
The study of structural features and the function of chaperones in Leishmania biology is providing opportunities (and challenges) for drug discovery and improving of current treatments against leishmaniasis.
American Psychological Association (APA)
Requena, Jose M.& Montalvo-Álvarez, Ana M.& Fraga, Jorge. 2015. Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. BioMed Research International،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1054959
Modern Language Association (MLA)
Requena, Jose M.…[et al.]. Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. BioMed Research International No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1054959
American Medical Association (AMA)
Requena, Jose M.& Montalvo-Álvarez, Ana M.& Fraga, Jorge. Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1054959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054959