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Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo
المؤلفون المشاركون
Li, Ping
Liu, Cong
Wang, Zhuo
Song, Yulong
Wu, Dan
Zheng, Xuan
Jin, Jin
Xu, Nannan
Li, Ling
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study investigated the effects of berberine on amelioration of hyperglycemia and hyperlipidemia and the mechanism involved in high glucose and high fat diet-induced diabetic hamsters.
Golden hamsters fed with high glucose and high fat diet were medicated with metformin, simvastatin, and low or high dose of berberine (50 and 100 mg·kg−1) for 6 weeks.
The results showed that the body weights were significantly lower in berberine-treated groups than control group.
Histological analyses revealed that the treatment of berberine inhibited hepatic fat accumulation.
Berberine significantly reduced plasma total cholesterol, triglyceride, free fatty acid, low density lipoprotein cholesterol, malondialdehyde, thiobarbituric acid-reactive substance, and 8-isoprostane level but significantly increased plasma superoxide dismutase activity.
Glucose and insulin levels were significantly reduced in metformin and berberine-treated groups.
Glucose tolerance tests documented that berberine-treated mice were more glucose tolerant.
Berberine treatment increased expression of skeletal muscle glucose transporter 4 mRNA and significantly decreased liver low density lipoprotein receptor mRNA expression.
The study suggested that berberine was effective in lowering blood glucose and lipids levels, reducing the body weight, and alleviating the oxidative stress in diabetic hamsters, which might be beneficial in reducing the cardiovascular risk factors in diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Cong& Wang, Zhuo& Song, Yulong& Wu, Dan& Zheng, Xuan& Li, Ping…[et al.]. 2015. Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Cong…[et al.]. Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Cong& Wang, Zhuo& Song, Yulong& Wu, Dan& Zheng, Xuan& Li, Ping…[et al.]. Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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