Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo
Joint Authors
Li, Ping
Liu, Cong
Wang, Zhuo
Song, Yulong
Wu, Dan
Zheng, Xuan
Jin, Jin
Xu, Nannan
Li, Ling
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study investigated the effects of berberine on amelioration of hyperglycemia and hyperlipidemia and the mechanism involved in high glucose and high fat diet-induced diabetic hamsters.
Golden hamsters fed with high glucose and high fat diet were medicated with metformin, simvastatin, and low or high dose of berberine (50 and 100 mg·kg−1) for 6 weeks.
The results showed that the body weights were significantly lower in berberine-treated groups than control group.
Histological analyses revealed that the treatment of berberine inhibited hepatic fat accumulation.
Berberine significantly reduced plasma total cholesterol, triglyceride, free fatty acid, low density lipoprotein cholesterol, malondialdehyde, thiobarbituric acid-reactive substance, and 8-isoprostane level but significantly increased plasma superoxide dismutase activity.
Glucose and insulin levels were significantly reduced in metformin and berberine-treated groups.
Glucose tolerance tests documented that berberine-treated mice were more glucose tolerant.
Berberine treatment increased expression of skeletal muscle glucose transporter 4 mRNA and significantly decreased liver low density lipoprotein receptor mRNA expression.
The study suggested that berberine was effective in lowering blood glucose and lipids levels, reducing the body weight, and alleviating the oxidative stress in diabetic hamsters, which might be beneficial in reducing the cardiovascular risk factors in diabetes.
American Psychological Association (APA)
Liu, Cong& Wang, Zhuo& Song, Yulong& Wu, Dan& Zheng, Xuan& Li, Ping…[et al.]. 2015. Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055005
Modern Language Association (MLA)
Liu, Cong…[et al.]. Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055005
American Medical Association (AMA)
Liu, Cong& Wang, Zhuo& Song, Yulong& Wu, Dan& Zheng, Xuan& Li, Ping…[et al.]. Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055005