Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis
المؤلفون المشاركون
Li, Xiao
Liu, Kang
Pan, Yongsheng
Zhang, Jing
Lv, Qiang
Hua, Lixin
Wang, Zengjun
Li, Jie
Yin, Changjun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Previous studies have investigated the relationships between osteopontin gene polymorphism rs1126616 and OPN levels and urolithiasis, but the results were controversial.
Our study aimed to clarify such relationships.
Methods.
A meta-analysis was performed by searching the databases Pubmed, Embase, and Web of Science for relevant studies.
Crude odds ratios (ORs) or standardised mean differences with 95% confidence intervals (CIs) were calculated to evaluate the strength of association.
Publication bias was estimated using Begg’s funnel plots and Egger’s regression test.
Results.
Overall, a significantly increased risk of urolithiasis was associated with OPN gene polymorphism rs1126616 for all the genetic models except recessive model.
When stratified by ethnicity, the results were significant only in Turkish populations.
For OPN level association, a low OPN level was detected in the urine of urolithiasis patients in large sample size subgroup.
Results also indicated that urolithiasis patients have lower OPN level in serum than normal controls.
Conclusion.
This meta-analysis revealed that the T allele of OPN gene polymorphism increased susceptibility to urolithiasis.
Moreover, significantly lower OPN levels were detected in urine and serum of urolithiasis patients than normal controls, thereby indicating that OPN has important functions in the progression of urolithiasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiao& Liu, Kang& Pan, Yongsheng& Zhang, Jing& Lv, Qiang& Hua, Lixin…[et al.]. 2015. Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiao…[et al.]. Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiao& Liu, Kang& Pan, Yongsheng& Zhang, Jing& Lv, Qiang& Hua, Lixin…[et al.]. Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر