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Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis
Joint Authors
Li, Xiao
Liu, Kang
Pan, Yongsheng
Zhang, Jing
Lv, Qiang
Hua, Lixin
Wang, Zengjun
Li, Jie
Yin, Changjun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Previous studies have investigated the relationships between osteopontin gene polymorphism rs1126616 and OPN levels and urolithiasis, but the results were controversial.
Our study aimed to clarify such relationships.
Methods.
A meta-analysis was performed by searching the databases Pubmed, Embase, and Web of Science for relevant studies.
Crude odds ratios (ORs) or standardised mean differences with 95% confidence intervals (CIs) were calculated to evaluate the strength of association.
Publication bias was estimated using Begg’s funnel plots and Egger’s regression test.
Results.
Overall, a significantly increased risk of urolithiasis was associated with OPN gene polymorphism rs1126616 for all the genetic models except recessive model.
When stratified by ethnicity, the results were significant only in Turkish populations.
For OPN level association, a low OPN level was detected in the urine of urolithiasis patients in large sample size subgroup.
Results also indicated that urolithiasis patients have lower OPN level in serum than normal controls.
Conclusion.
This meta-analysis revealed that the T allele of OPN gene polymorphism increased susceptibility to urolithiasis.
Moreover, significantly lower OPN levels were detected in urine and serum of urolithiasis patients than normal controls, thereby indicating that OPN has important functions in the progression of urolithiasis.
American Psychological Association (APA)
Li, Xiao& Liu, Kang& Pan, Yongsheng& Zhang, Jing& Lv, Qiang& Hua, Lixin…[et al.]. 2015. Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055013
Modern Language Association (MLA)
Li, Xiao…[et al.]. Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055013
American Medical Association (AMA)
Li, Xiao& Liu, Kang& Pan, Yongsheng& Zhang, Jing& Lv, Qiang& Hua, Lixin…[et al.]. Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055013