Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease
المؤلفون المشاركون
Li, Ji
Ji, Kang-ting
Zhang, Su-qin
Wang, Guo-qiang
Zhu, Yong-jin
Wang, Lu-ping
Liao, Lian-ming
Tang, Ji-fei
Wang, Xiaoyan
Lu, Qin
Xue, Yangjing
Qian, Lu
Wu, Wenwu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine.
This study explored the association of 173G/C polymorphism of the MIF gene with coronary heart disease (CHD).
Methods.
Sequencing was carried out after polymerase chain reaction with DNA specimens from 186 volunteers without CHD and 70 patients with CHD.
Plasma MIF levels on admission were measured by ELISA.
Patients were classified into either stable angina pectoris (SAP) or unstable angina pectoris (UAP).
Genotype distribution between cases and controls and the association of patients’ genotypes with MIF level and plaque stability were statistically evaluated (ethical approval number: 2012-01).
Results.
The frequency of the C genotype was higher in CHD patients than in the control (P=0.014).
The frequency of the 173*CC genotype was higher in CHD patients than in the control (P=0.005).
The plasma MIF level was higher in MIF173*C carriers than in MIF173*G carriers (P=0.033).
CHD patients had higher plasma MIF levels than the control (P=0.000).
Patients with UAP had higher plasma MIF levels than patients with SAP (P=0.014).
Conclusions.
These data suggest that MIF −173G/C polymorphism may be related to the development of CHD in a Chinese population.
Plasma MIF level is a predictor of plaque stability.
This trial is registered with NCT01750502 .
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ji, Kang-ting& Wang, Xiaoyan& Li, Ji& Lu, Qin& Wang, Guo-qiang& Xue, Yangjing…[et al.]. 2015. Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055015
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ji, Kang-ting…[et al.]. Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055015
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ji, Kang-ting& Wang, Xiaoyan& Li, Ji& Lu, Qin& Wang, Guo-qiang& Xue, Yangjing…[et al.]. Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055015
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055015
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر