Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease
Joint Authors
Li, Ji
Ji, Kang-ting
Zhang, Su-qin
Wang, Guo-qiang
Zhu, Yong-jin
Wang, Lu-ping
Liao, Lian-ming
Tang, Ji-fei
Wang, Xiaoyan
Lu, Qin
Xue, Yangjing
Qian, Lu
Wu, Wenwu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine.
This study explored the association of 173G/C polymorphism of the MIF gene with coronary heart disease (CHD).
Methods.
Sequencing was carried out after polymerase chain reaction with DNA specimens from 186 volunteers without CHD and 70 patients with CHD.
Plasma MIF levels on admission were measured by ELISA.
Patients were classified into either stable angina pectoris (SAP) or unstable angina pectoris (UAP).
Genotype distribution between cases and controls and the association of patients’ genotypes with MIF level and plaque stability were statistically evaluated (ethical approval number: 2012-01).
Results.
The frequency of the C genotype was higher in CHD patients than in the control (P=0.014).
The frequency of the 173*CC genotype was higher in CHD patients than in the control (P=0.005).
The plasma MIF level was higher in MIF173*C carriers than in MIF173*G carriers (P=0.033).
CHD patients had higher plasma MIF levels than the control (P=0.000).
Patients with UAP had higher plasma MIF levels than patients with SAP (P=0.014).
Conclusions.
These data suggest that MIF −173G/C polymorphism may be related to the development of CHD in a Chinese population.
Plasma MIF level is a predictor of plaque stability.
This trial is registered with NCT01750502 .
American Psychological Association (APA)
Ji, Kang-ting& Wang, Xiaoyan& Li, Ji& Lu, Qin& Wang, Guo-qiang& Xue, Yangjing…[et al.]. 2015. Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055015
Modern Language Association (MLA)
Ji, Kang-ting…[et al.]. Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055015
American Medical Association (AMA)
Ji, Kang-ting& Wang, Xiaoyan& Li, Ji& Lu, Qin& Wang, Guo-qiang& Xue, Yangjing…[et al.]. Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055015