Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos
المؤلفون المشاركون
Li, Yixue
Liu, Tiancheng
Yu, Lin
Ding, Guohui
Wang, Zhen
Liu, Lei
Li, Hong
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Evolutionary developmental biology (EVO-DEVO) tries to decode evolutionary constraints on the stages of embryonic development.
Two models—the “funnel-like” model and the “hourglass” model—have been proposed by investigators to illustrate the fluctuation of selective pressure on these stages.
However, selective indices of stages corresponding to mammalian preimplantation embryonic development (PED) were undetected in previous studies.
Based on single cell RNA sequencing of stages during human PED, we used coexpression method to identify gene modules activated in each of these stages.
Through measuring the evolutionary indices of gene modules belonging to each stage, we observed change pattern of selective constraints on PED for the first time.
The selective pressure decreases from the zygote stage to the 4-cell stage and increases at the 8-cell stage and then decreases again from 8-cell stage to the late blastocyst stages.
Previous EVO-DEVO studies concerning the whole embryo development neglected the fluctuation of selective pressure in these earlier stages, and the fluctuation was potentially correlated with events of earlier stages, such as zygote genome activation (ZGA).
Such oscillation in an earlier stage would further affect models of the evolutionary constraints on whole embryo development.
Therefore, these earlier stages should be measured intensively in future EVO-DEVO studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Tiancheng& Yu, Lin& Ding, Guohui& Wang, Zhen& Liu, Lei& Li, Hong…[et al.]. 2015. Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055023
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Tiancheng…[et al.]. Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055023
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Tiancheng& Yu, Lin& Ding, Guohui& Wang, Zhen& Liu, Lei& Li, Hong…[et al.]. Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055023
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055023
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر