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Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos
Joint Authors
Li, Yixue
Liu, Tiancheng
Yu, Lin
Ding, Guohui
Wang, Zhen
Liu, Lei
Li, Hong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Evolutionary developmental biology (EVO-DEVO) tries to decode evolutionary constraints on the stages of embryonic development.
Two models—the “funnel-like” model and the “hourglass” model—have been proposed by investigators to illustrate the fluctuation of selective pressure on these stages.
However, selective indices of stages corresponding to mammalian preimplantation embryonic development (PED) were undetected in previous studies.
Based on single cell RNA sequencing of stages during human PED, we used coexpression method to identify gene modules activated in each of these stages.
Through measuring the evolutionary indices of gene modules belonging to each stage, we observed change pattern of selective constraints on PED for the first time.
The selective pressure decreases from the zygote stage to the 4-cell stage and increases at the 8-cell stage and then decreases again from 8-cell stage to the late blastocyst stages.
Previous EVO-DEVO studies concerning the whole embryo development neglected the fluctuation of selective pressure in these earlier stages, and the fluctuation was potentially correlated with events of earlier stages, such as zygote genome activation (ZGA).
Such oscillation in an earlier stage would further affect models of the evolutionary constraints on whole embryo development.
Therefore, these earlier stages should be measured intensively in future EVO-DEVO studies.
American Psychological Association (APA)
Liu, Tiancheng& Yu, Lin& Ding, Guohui& Wang, Zhen& Liu, Lei& Li, Hong…[et al.]. 2015. Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055023
Modern Language Association (MLA)
Liu, Tiancheng…[et al.]. Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055023
American Medical Association (AMA)
Liu, Tiancheng& Yu, Lin& Ding, Guohui& Wang, Zhen& Liu, Lei& Li, Hong…[et al.]. Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055023