Alendronate-Eluting Biphasic Calcium Phosphate (BCP)‎ Scaffolds Stimulate Osteogenic Differentiation

المؤلفون المشاركون

Lee, Bo-ram
Jeong, Won Jae
Lee, Deok-Won
Kang, Eun Young
Jeong, Myeong Seon
Kim, Hak-Jun
Yun, Young-Pil
Park, Kyeongsoon
Song, Hae-Ryong
Kim, Sung Eun

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-06-29

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes.

However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation.

To enhance osteogenic differentiation, we prepared alendronate- (ALN-) eluting BCP scaffolds.

The coating of ALN on BCP scaffolds was confirmed by scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR).

An in vitro release study showed that release of ALN from ALN-eluting BCP scaffolds was sustained for up to 28 days.

In vitro results revealed that MG-63 cells grown on ALN-eluting BCP scaffolds exhibited increased ALP activity and calcium deposition and upregulated gene expression of Runx2, ALP, OCN, and OPN compared with the BCP scaffold alone.

Therefore, this study suggests that ALN-eluting BCP scaffolds have the potential to effectively stimulate osteogenic differentiation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kim, Sung Eun& Yun, Young-Pil& Lee, Deok-Won& Kang, Eun Young& Jeong, Won Jae& Lee, Bo-ram…[et al.]. 2015. Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055055

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kim, Sung Eun…[et al.]. Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055055

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kim, Sung Eun& Yun, Young-Pil& Lee, Deok-Won& Kang, Eun Young& Jeong, Won Jae& Lee, Bo-ram…[et al.]. Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055055

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1055055