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Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation
Joint Authors
Lee, Bo-ram
Jeong, Won Jae
Lee, Deok-Won
Kang, Eun Young
Jeong, Myeong Seon
Kim, Hak-Jun
Yun, Young-Pil
Park, Kyeongsoon
Song, Hae-Ryong
Kim, Sung Eun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes.
However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation.
To enhance osteogenic differentiation, we prepared alendronate- (ALN-) eluting BCP scaffolds.
The coating of ALN on BCP scaffolds was confirmed by scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR).
An in vitro release study showed that release of ALN from ALN-eluting BCP scaffolds was sustained for up to 28 days.
In vitro results revealed that MG-63 cells grown on ALN-eluting BCP scaffolds exhibited increased ALP activity and calcium deposition and upregulated gene expression of Runx2, ALP, OCN, and OPN compared with the BCP scaffold alone.
Therefore, this study suggests that ALN-eluting BCP scaffolds have the potential to effectively stimulate osteogenic differentiation.
American Psychological Association (APA)
Kim, Sung Eun& Yun, Young-Pil& Lee, Deok-Won& Kang, Eun Young& Jeong, Won Jae& Lee, Bo-ram…[et al.]. 2015. Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055055
Modern Language Association (MLA)
Kim, Sung Eun…[et al.]. Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055055
American Medical Association (AMA)
Kim, Sung Eun& Yun, Young-Pil& Lee, Deok-Won& Kang, Eun Young& Jeong, Won Jae& Lee, Bo-ram…[et al.]. Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055055