Lesser-Known Molecules in Ovarian Carcinogenesis
المؤلفون المشاركون
Lozneanu, Ludmila
Cojocaru, Elena
Giuşcă, Simona Eliza
Cărăuleanu, Alexandru
Căruntu, Irina-Draga
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Currently, the deciphering of the signaling pathways brings about new advances in the understanding of the pathogenic mechanism of ovarian carcinogenesis, which is based on the interaction of several molecules with different biochemical structure that, consequently, intervene in cell metabolism, through their role as regulators in proliferation, differentiation, and cell death.
Given that the ensemble of biomarkers in OC includes more than 50 molecules the interest of the researchers focuses on the possible validation of each one’s potential as prognosis markers and/or therapeutic targets.
Within this framework, this review presents three protein molecules: ALCAM, c-FLIP, and caveolin, motivated by the perspectives provided through the current limited knowledge on their role in ovarian carcinogenesis and on their potential as prognosis factors.
Their structural stability, once altered, triggers the initiation of the sequences characteristic for ovarian carcinogenesis, through their role as modulators for several signaling pathways, contributing to the disruption of cellular junctions, disturbance of pro-/antiapoptotic equilibrium, and alteration of transmission of the signals specific for the molecular pathways.
For each molecule, the text is built as follows: (i) general remarks, (ii) structural details, and (iii) particularities in expression, from different tumors to landmarks in ovarian carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lozneanu, Ludmila& Cojocaru, Elena& Giuşcă, Simona Eliza& Cărăuleanu, Alexandru& Căruntu, Irina-Draga. 2015. Lesser-Known Molecules in Ovarian Carcinogenesis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055063
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lozneanu, Ludmila…[et al.]. Lesser-Known Molecules in Ovarian Carcinogenesis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055063
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lozneanu, Ludmila& Cojocaru, Elena& Giuşcă, Simona Eliza& Cărăuleanu, Alexandru& Căruntu, Irina-Draga. Lesser-Known Molecules in Ovarian Carcinogenesis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055063
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055063
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر