Lesser-Known Molecules in Ovarian Carcinogenesis
Joint Authors
Lozneanu, Ludmila
Cojocaru, Elena
Giuşcă, Simona Eliza
Cărăuleanu, Alexandru
Căruntu, Irina-Draga
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Currently, the deciphering of the signaling pathways brings about new advances in the understanding of the pathogenic mechanism of ovarian carcinogenesis, which is based on the interaction of several molecules with different biochemical structure that, consequently, intervene in cell metabolism, through their role as regulators in proliferation, differentiation, and cell death.
Given that the ensemble of biomarkers in OC includes more than 50 molecules the interest of the researchers focuses on the possible validation of each one’s potential as prognosis markers and/or therapeutic targets.
Within this framework, this review presents three protein molecules: ALCAM, c-FLIP, and caveolin, motivated by the perspectives provided through the current limited knowledge on their role in ovarian carcinogenesis and on their potential as prognosis factors.
Their structural stability, once altered, triggers the initiation of the sequences characteristic for ovarian carcinogenesis, through their role as modulators for several signaling pathways, contributing to the disruption of cellular junctions, disturbance of pro-/antiapoptotic equilibrium, and alteration of transmission of the signals specific for the molecular pathways.
For each molecule, the text is built as follows: (i) general remarks, (ii) structural details, and (iii) particularities in expression, from different tumors to landmarks in ovarian carcinoma.
American Psychological Association (APA)
Lozneanu, Ludmila& Cojocaru, Elena& Giuşcă, Simona Eliza& Cărăuleanu, Alexandru& Căruntu, Irina-Draga. 2015. Lesser-Known Molecules in Ovarian Carcinogenesis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055063
Modern Language Association (MLA)
Lozneanu, Ludmila…[et al.]. Lesser-Known Molecules in Ovarian Carcinogenesis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055063
American Medical Association (AMA)
Lozneanu, Ludmila& Cojocaru, Elena& Giuşcă, Simona Eliza& Cărăuleanu, Alexandru& Căruntu, Irina-Draga. Lesser-Known Molecules in Ovarian Carcinogenesis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055063