Effects of Mitochondrial Uncoupling Protein 2 Inhibition by Genipin in Human Cumulus Cells
المؤلفون المشاركون
Ge, Hongshan
Zhang, Fan
Shan, Dan
Chen, Hua
Wang, Xiaona
Ling, Chao
Xi, HaiTao
Huang, Jianying
Zhu, ChunFang
Lv, Jeiqiang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
UCP2 plays a physiological role by regulating mitochondrial biogenesis, maintaining energy balance, ROS elimination, and regulating cellular autophagy in numerous tissues.
But the exact roles of UCP2 in cumulus cells are still not clear.
Genipin, a special UCP2 inhibitor, was added into the cultural medium to explore the roles of UCP2 in human cumulus cells.
There were no significant differences in ATP and mitochondrial membrane potential levels in cumulus cells from UCP2 inhibiting groups as compared with the control.
The levels of ROS and Mn-SOD were markedly elevated after UCP2 inhibited Genipin.
However, the ratio of reduced GSH to GSSG significantly declined after treatment with Genipin.
UCP2 inhibition by Genipin also resulted in obvious increase in the active caspase-3, which accompanied the decline of caspase-3 mRNA.
The level of progesterone in culture medium declined obviously after Genipin treatment.
But there was no significant difference in estradiol concentrations.
This study indicated that UCP2 is expressed in human cumulus cells and plays important roles on mediate ROS production, apoptotic process, and steroidogenesis, suggesting UCP2 may be involved in regulation of follicle development and oocyte maturation and quality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ge, Hongshan& Zhang, Fan& Shan, Dan& Chen, Hua& Wang, Xiaona& Ling, Chao…[et al.]. 2015. Effects of Mitochondrial Uncoupling Protein 2 Inhibition by Genipin in Human Cumulus Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055067
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ge, Hongshan…[et al.]. Effects of Mitochondrial Uncoupling Protein 2 Inhibition by Genipin in Human Cumulus Cells. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055067
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ge, Hongshan& Zhang, Fan& Shan, Dan& Chen, Hua& Wang, Xiaona& Ling, Chao…[et al.]. Effects of Mitochondrial Uncoupling Protein 2 Inhibition by Genipin in Human Cumulus Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055067
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055067
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر