Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke
المؤلفون المشاركون
Schini-Kerth, Valérie B.
Wolff, Valérie
Zoll, Joffrey
Schlagowski, Anna-Isabel
Rouyer, Olivier
Singh, François
Marescaux, Christian
Raul, Jean-Sébastien
Geny, Bernard
Charles, Anne-Laure
Auger, Cyril
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Cannabis has potential therapeutic use but tetrahydrocannabinol (THC), its main psychoactive component, appears as a risk factor for ischemic stroke in young adults.
We therefore evaluate the effects of THC on brain mitochondrial function and oxidative stress, key factors involved in stroke.
Maximal oxidative capacities Vmax (complexes I, III, and IV activities), Vsucc (complexes II, III, and IV activities), Vtmpd (complex IV activity), together with mitochondrial coupling (Vmax/V0), were determined in control conditions and after exposure to THC in isolated mitochondria extracted from rat brain, using differential centrifugations.
Oxidative stress was also assessed through hydrogen peroxide (H2O2) production, measured with Amplex Red.
THC significantly decreased Vmax (−71%; P<0.0001), Vsucc (−65%; P<0.0001), and Vtmpd (−3.5%; P<0.001).
Mitochondrial coupling (Vmax/V0) was also significantly decreased after THC exposure (1.8±0.2 versus 6.3±0.7; P<0.001).
Furthermore, THC significantly enhanced H2O2 production by cerebral mitochondria (+171%; P<0.05) and mitochondrial free radical leak was increased from 0.01±0.01 to 0.10±0.01% (P<0.001).
Thus, THC increases oxidative stress and induces cerebral mitochondrial dysfunction.
This mechanism may be involved in young cannabis users who develop ischemic stroke since THC might increase patient’s vulnerability to stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wolff, Valérie& Schlagowski, Anna-Isabel& Rouyer, Olivier& Charles, Anne-Laure& Singh, François& Auger, Cyril…[et al.]. 2015. Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wolff, Valérie…[et al.]. Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wolff, Valérie& Schlagowski, Anna-Isabel& Rouyer, Olivier& Charles, Anne-Laure& Singh, François& Auger, Cyril…[et al.]. Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر