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Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors
المؤلفون المشاركون
Martín-Márquez, Beatriz Teresita
Corona-Sanchez, Esther Guadalupe
Gómez-Bañuelos, Eduardo
Navarro-Hernandez, Rosa Elena
Martínez-García, Erika Aurora
Figueroa-Sánchez, Mauricio
Macias-Reyes, Héctor
Nuñez-Atahualpa, María Alejandra
Andrade-Garduño, Javier
Gonzalez-Lopez, Laura
Vázquez-Del Mercado, Mónica
Nuñez-Atahualpa, Lourdes
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The main cause of death in rheumatoid arthritis (RA) is cardiovascular events.
We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) in RA patients.
Methods.
Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC) were studied.
All groups were assessed for atherogenic index of plasma (AIP) and cIMT.
Anti-CCP, C-reactive protein (CRP), and levels of tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA).
Results.
The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative (P<0.001).
Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNFα and IL-6 (P<0.01), and lower levels of high density lipoprotein cholesterol (HDL-c) (P=0.02).
The cIMT correlated with levels of anti-CCP (r=0.513, P=0.001), CRP (r=0.799, P<0.001), TNFα (r=0.642, P=0.001), and IL-6 (r=0.751, P<0.001).
In multiple regression analysis, cIMT was associated with CRP (P<0.001) and anti-CCP levels (P=0.03).
Conclusions.
Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vázquez-Del Mercado, Mónica& Nuñez-Atahualpa, Lourdes& Figueroa-Sánchez, Mauricio& Gómez-Bañuelos, Eduardo& Rocha-Muñoz, Alberto Daniel& Martín-Márquez, Beatriz Teresita…[et al.]. 2015. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055118
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vázquez-Del Mercado, Mónica…[et al.]. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055118
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vázquez-Del Mercado, Mónica& Nuñez-Atahualpa, Lourdes& Figueroa-Sánchez, Mauricio& Gómez-Bañuelos, Eduardo& Rocha-Muñoz, Alberto Daniel& Martín-Márquez, Beatriz Teresita…[et al.]. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055118
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055118
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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